Publications – Groupe « Recherche sur les maladies de la rétine » / « Retinal disorder research » group

Articles

Erjavec E, Angée C, Hadjadj D, Passet B, David P, Kostic C, Dodé E, Zanlonghi X, Cagnard N, Nedelec B, Crippa SV, Bole-Feysot C, Zarhrate M, Creuzet S, Castille J, Vilotte JL, Calvas P, Plaisancié J, Chassaing N, Kaplan J, Rozet JM, Taie LF. Congenital microcoria deletion in mouse links Sox21 dysregulation to disease and suggests a role for TGFB2 in glaucoma and myopia. Am J Hum Genet. 2024; 111(10):2265-2282. doi: 10.1016/j.ajhg.2024.08.019

Arsenijevic Y*, Chang N, Mercey O, El Fersioui Y, Koskiniemi-Kuendig H, Joubert C, Bemelmans AP, Rivolta C, Banin E, Sharon D, Guichard P, Hamel V, Kostic C*. Fine-tuning FAM161A gene augmentation therapy to restore retinal function. EMBO Mol Med. 2024; 16(4):805-822. doi: 10.1038/s44321-024-00053-x.

Matsevich C, Gopalakrishnan P, Chang N, Obolensky A, Beryozkin A, Salameh M, Kostic C*, Sharon D*, Arsenijevic Y*, Banin E* Gene augmentation therapy attenuates retinal degeneration in a knockout mouse model of Fam161a retinitis pigmentosa. Mol Ther. 2023 Aug 14:S1525-0016(23)00443-4. doi: 10.1016/j.ymthe.2023.08.011

Arsenijevic Y, Berger A, Udry F, Kostic C, Lentiviral Vectors for Ocular Gene Therapy, Pharmaceutics 2022, 14(8), 1605. doi: 10.3390/pharmaceutics14081605

Mercey O., Kostic C., Bertiaux E., Giroud A., Sadian Y., Gaboriau DCA, Morrison C.G., Chang N., Arsenijevic Y., Guichard P. et al., The connecting cilium inner scaffold provides a structural foundation that protects against retinal degeneration. 2022/06. PLoS biology, 20 (6) pp. e3001649. doi: 10.1371/journal.pbio.3001649

Mbefo M., Berger A., Schouwey K., Gérard X., Kostic C., Beryozkin A., Sharon D., Dolfuss H., Munier F., Tran H.V. et al. Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy 2021/08/28. International journal of molecular sciences, 22 (17) p. 9331. Peer-reviewed. doi: 10.3390/ijms22179331.

Kostic C., Crippa S.V., Leon L., Hamel C., Meunier I., Kawasaki A. Quantification of the early pupillary dilation kinetic to assess rod and cone activity 2021/05/05. Scientific reports, 11 (1) p. 9549. Peer-reviewed. doi: 10.1038/s41598-021-88915-z.

Beryozkin A, Matsevich C, Obolensky A, Kostic C, Arsenijevic Y, Wolfrum U, Banin E, Sharon D. A new mouse model for retinal degeneration due to Fam161a deficiency. Sci Rep. 2021 Jan 21;11(1):2030. doi: 10.1038/s41598-021-81414-1.

Potic J, Mbefo M, Berger A, Nicolas M, Wanner D, Kostic C, Matet A, Behar-Cohen F, Moulin A, Arsenijevic A. An in vitro model of human retinal detachment reveals successive death pathway activations. (2020) Front. Neurosci. Nov 26;14:571293. doi: 10.3389/fnins.2020.571293

Udry F, Decembrini S, Gamm DM, Déglon N, Kostic C and Arsenijevic Y. Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level. (2020) Sci Rep Jun 1;10(1):8890. doi: 10.1038/s41598-020-65657-y.

Kircher N, Crippa SV, Martin C, Kawasaki A and , Kostic C*. Maturation of the pupil light response occurs during adulthood in mice. (2019) Front Neurol 10(56). doi: 10.3389/fneur.2019.00056.

Matet A, Kostic C*, Bemelmans AP, Moulin A, Rosolen RG, Martin S, Mavilio F, Amirjanians V, Stieger K, Lorenz B, Behar-Cohen F and Arsenijevic Y* Evaluation of tolerance to lentiviral LV-RPE65 gene therapy vector after subretinal delivery in non-human primates. (2017) Transl Res, 188:40-57.

Diessler S, Kostic C, Arsenijevic Y, Kawasaki A, Franken P. Rai1 frees mice from the repression of active wake behaviors by light. (2017) Elife. 26;6

Ataca D, Caikovski M, Piersigilli A, Moulin A, Benarafa C, Earp SE, Guri Y, Kostic C, Arsenijevic Y, Soininen R, Apte SS, Brisken C. Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development. (2016) Biol Open. 15;5(11):1585-1594

Dinet V, Ciccotosto GD, Delaunay K, Borras C, Ranchon-Cole I, Kostic C, Savoldelli M, El Sanharawi M, Jonet L, Pirou C, An N, Abitbol M, Arsenijevic Y, Behar-Cohen F, Cappai R, Mascarelli F. Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. (2016) Mol Brain 8;9(1):64.

Kostic C*, Crippa SV, Martin C, Kardon R H, Arsenijevic Y and Kawasaki A*. Determination of rod and cone influence to the early and late dynamic of the pupillary light response. (2016) IOVS 57, 2501-2508.

Kostic C*, Arsenijevic Y*. Animal modeling for inherited central vision loss. (2016) J Pathol. 238(2):300-310

Askou AL, Aagaard L, Kostic C, Arsenijevic Y, Hollensen AK, Bek T, Jensen TG, Mikkelsen JG1, Corydon TJ. Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors. (2015) Mol Ther Methods Clin Dev. Jan 28;2:14064

Sarode B, Nowell CS, Ihm J, Kostic C, Arsenijevic Y, Moulin AP, Schorderet DF, Beermann F, Radtke F. Notch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation. (2014) Pigment Cell Melanoma Res. 27(4):580-9

Cachafeiro M, Bemelmans AP, Samardzija M, Afanasieva T, Pournaras JA, Grimm C, Kostic C, Philippe S, Wenzel A, Arsenijevic Y. Hyperactivation of retina by light in mice leads to photoreceptor cell death mediated by VEGF and retinal pigment epithelium permeability. (2013) Cell Death Dis. 4:e781.

Kostic C, Lillico SG, Crippa SV, Grandchamp N, Pilet H, Philippe S, Lu Z, King TJ, Mallet J, Sarkis C, Arsenijevic Y, Whitelaw CB. Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy. (2013) PLoS One 8(8):e71363

Askou AL, Pournaras JA, Pihlmann M, Svalgaard JD, Arsenijevic Y, Kostic C, Bek T, Dagnaes-Hansen F, Mikkelsen JG, Jensen TG, Corydon TJ. Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA. (2012) J Gene Med. 14(11):632-41

Di Gioia SA, Letteboer SJ, Kostic C, Bandah-Rozenfeld D, Hetterschijt L, Sharon D, Arsenijevic Y, Roepman R, Rivolta C. FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies. (2012) Hum Mol Genet. 21(23):5174-84.

Calame M, Cachafeiro M, Philippe S, Tekaya M, Wanner D, Sarkis C, Mallet J, Kostic C, Arsenijevic Y Retinal degeneration progression changes lentiviral cell targeting in the retina (2011) PloS One 6(8):e23782.

Kostic C*, Crippa SV, Pignat V, Bemelmans A-P, Samardzija M, Grimm C, Wenzel A and. Arsenijevic Y. Gene therapy regenerates protein expression in cone photoreceptors in Rpe65 ^R91W/R91W mice (2011) PloS One 6(2):e16588

Buceta M, Galbete JL, Kostic C, Arsenijevic Y, Mermod N. Use of human MAR elements to improve retroviral vector production. (2010) Gene Therapy. 18(1):7-13.

Cachafeiro M, Bemelmans AP, Canola K, Pignat V, Crippa SV, Kostic C, Arsenijevic Y. Remaining rod activity mediates visual behaviour in adult Rpe65-/- mice. (2010) Invest Ophthalmol Vis Sci 51(12):6835-42.

Viet Tran H, Shorderet D, Kostic C, Munier FL, Arsenijevic Y. Thérapie génique des rétinopathies héréditaires : premiers résultats et prise en charge des patients avant son introduction en Suisse. (2009) Rev Med Suisse. 5(186):118-23.

Samardzija M, Tanimoto N, Kostic C, Beck S, Oberhauser V, Joly S, Thiersch M, Fahl E, Arsenijevic Y, von Lintig J, Wenzel A, Seeliger MW, Grimm C. In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death.(2009) Hum Mol Genet.18(7):1266-75

Bemelmans AP, Kostic C, Cachafeiro M, Crippa SV, Wanner D, Tekaya M, Wenzel A, Arsenijevic Y. Lentiviral gene transfer-mediated cone vision restoration in RPE65 knockout mice. (2008) Adv Exp Med Biol. 613:89-95

Bemelmans AP^† , Kostic C^† , Crippa SV, Hauswirth WW, Lem J, Munier FL, Seeliger MW, Wenzel A and Arsenijevic Y Lentiviral-mediated transfer of the RPE65 cDNA rescues both survival and function of cone photoreceptors in a mouse model of Leber Congenital Amaurosis. (2006) PLoS Medicine. 3(10): e347^† co-first authors

Mehri-Soussi F, Angenieux B, Canola K, Kostic C, Tekaya M, Hornfeld D and Arsenijevic Y High Yield of Cells Committed to the Photoreceptor Fate from Expanded Mouse Retinal Stem Cells. (2006) Stem Cells. 24(9):2060-70.

Zencak D, Lingbeek M, Kostic C, Tekaya M, Tanger E, Hornfeld D, Jaquet M, Munier FL, Schorderet DF, van Lohuizen M and Arsenijevic Y Bmi1 loss produces ans increase in astroglial cells and a decrease in neural stem cell population and proliferation. (2005) J Neurosci. 25(24):5774-5783

Gruter O, Kostic C*, Perez MTR, Zografos L, Munier FL, Schorderet DF and Arsenijevic Y* Lentiviral vector-mediated gene transfer in adult mouse photoreceptors is impaired by a physical barrier. (2005) Gene Therapy. 12(11):942-947

Arsenijevic Y, Taverney N, Kostic C, Tekaya M, Riva F, Zografos L, Schorderet DF, Francis Munier. (2003) Non-neural tissues of the adult human eye: a new source of neurons? Invest Ophthalmol Vis Sci 44: 799-807.

Kostic, C., Chiodini, F., Salmon, P., Wiznerowicz, M., Deglon, N., Hornfeld, D., Trono, T., Aebischer, P., Schorderet, D.F., Munier, F.L. and Arsenijevic, Y. (2003). Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina. Gene Ther 10(9):818-821.

Van Adel, B.A., Kostic, C., Deglon, N., Ball, A.K. and Arsenijevic, Y. (2003). Delivery of Ciliary neurotrophic factor via lentiviral-mediated transfer protects rapidly axotomized retinal ganglion cells for an extended period of time. Hum Gene Ther; 14(2):103-15.

Arsenijevic, Y., Villemure, J.G., Brunet, J.F., Bloch, J.J., Déglon, N., Kostic, C., Zurn, A. and Aebischer, P. (2001). Isolation of multipotent neural precursors residing in the cortex of the adult human brain. Exp Neurol.; 170(1):48-62.

Kostic, C. and Shaw, P.H. (2000). Isolation and characterization of sixteen novel p53 response genes. Oncogene; 19(35):3978-87.

Poux, S., Kostic, C. and Pirrotta V. (1996). Hunchback-independent silencing of late Ubx enhancers by a Polycomb Group Response Element. EMBO J; 15(17):4713-22.

Book Chapter

Bemelmans A-P, Kostic C, Wenzel A., Jaquet M, Seeliger M, Hauswirth W., Lem J, Schorderet DF, Munier FL, Arsenijevic Y RPE65 promoter activity in the retina of Leber congenital amaurosis genetic mouse models, as revealed by lentiviral-mediated transfer of the GFP gene, in « Retinal Degenerative Diseases « edited by Joe G. Hollyfield, Robert E. Anderson, and Matthew M. LaVail. Springer, New York, NY, 2006 pgs 247-253

Bemelmans A-P, Kostic C., Hornfeld D, Jaquet M, Crippa S, Hauswirth WW, Lem J, Schorderet D, Munier FL , Wenzel A. and Arsenijevic Y. Lentiviral vectors containing a retinal pigment epithelium specific promoter for Leber congenital amaurosis gene therapy. In Retinal Degenerative Diseases, JG Hollyfield, RE Anderson and MM LaVail eds. Springer, New York, 2005.